human GSK3B Adenovirus

Name 
Ad-h-GSK3B
Cat No 
ADV-210586
Availability
4-5 weeks

This is an Adenovirus expressing Human COBL.

ADV-210586
Ad-h-GSK3B

Ready-to-use Adenovirus expressing Human GSK3B (glycogen synthase kinase 3 beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B
Description (eCommerce)
Glycogen synthase kinase 3 beta (GSK3beta) is a proline-directed serine-threonine kinase identified as a kinase responsible for the phosphorylation and inactivation of glycogen synthase. GSK3beta is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. In addition to the Wnt-signaling pathway, GSK3beta is also involved in the Hedgehog, Notch and insulin signaling pathways.
Description (Vector)
GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
2932
Gene Name (eCommerce)
glycogen synthase kinase 3 beta
Gene Name (Vector)
glycogen synthase kinase 3 beta
Gene Symbol
GSK3B
HGNC ID
HGNC:4617
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1263
ORF Size (bp)
1263 bp
Protein Name (eCommerce)
Glycogen synthase kinase-3 beta
RefSeq ID
NM_002093
RefSeq Synonyms
NM_002093, NM_001146156, BC012760, BC000251,
Research Areas
Alzheimer's Disease,Apoptosis,Autophagy,Axon Guidance,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Colorectal Cancer,Cytoskeleton,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,Hedgehog Signaling,Hippo Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,LKB1 Signaling,Metabolism/Metabolic Process,mTOR Signaling,Neurobiology,Neurodegeneration,Neurodevelopment,Neurogenesis,NFAT Signaling,NGF Signaling,Notch Signaling,p53 Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prolactin Signaling,Prostate Cancer,RNA Binding,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,Transcription Factor/Regulator,TWEAK Signaling,VEGF Signaling,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
Glycogen synthase kinase 3 beta (GSK3beta) is a proline-directed serine-threonine kinase identified as a kinase responsible for the phosphorylation and inactivation of glycogen synthase. GSK3beta is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. In addition to the Wnt-signaling pathway, GSK3beta is also involved in the Hedgehog, Notch and insulin signaling pathways.
UniGene ID
Hs.593022
UniProt ID (eCommerce)
P49841

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.