human FOXO1 Adenovirus

FKH1; FKHR; forkhead box protein O1; forkhead box protein O1A; Forkhead in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FOXO1A

Forkhead box protein 01A (FOXO1a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO1 is a transcription factor that integrates cell signals to mediate metabolism, the cell cycle, DNA repair, and response to cellular stress. In response to insulin, FOXO1 is phosphorylated by Akt and excluded from the nucleus and subsequently degraded. Over-expressed cytoplasmic FOXO1 interacts with TSC2 to cause its degradation and subsequent activation of the mTOR pathway; while nuclear localization inhibits the mTOR pathway.

FOXO1 belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.

2308

forkhead box O1

forkhead box O1

FOXO1

HGNC:3819

9606.0

1968

1968 bp

Forkhead box protein O1

NM_002015

NM_002015, BC070065, BC021981,

Aging,Apoptosis,B-cell Receptor Signaling,Breast Cancer,Cancer,Cardiovascular,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,FoxO Signaling,Gene Expression,Glioma,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Leptin Signaling,MAPK Signaling,Metabolism/Metabolic Process,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,SCF-KIT Signaling,Signal Transduction,TGF-beta Signaling,TNF Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer

cancer,cardiovascular,cell_biology,genetics,immunology,metabolism,neurobiology,signal_transduction,stem_cell_biology,transcription_translation

human

Forkhead box protein 01A (FOXO1a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO1 is a transcription factor that integrates cell signals to mediate metabolism, the cell cycle, DNA repair, and response to cellular stress. In response to insulin, FOXO1 is phosphorylated by Akt and excluded from the nucleus and subsequently degraded. Over-expressed cytoplasmic FOXO1 interacts with TSC2 to cause its degradation and subsequent activation of the mTOR pathway; while nuclear localization inhibits the mTOR pathway.

Hs.370666

Q12778