human FAM125B Adenovirus
This is an Adenovirus expressing Human FAM125B.
ADV-208372
Ad-h-FAM125B
Ready-to-use Adenovirus expressing Human MVB12B (multivesicular body subunit 12B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C9orf28; FAM125B
Description (Vector)
FAM125B is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
89853
Gene Name (Vector)
multivesicular body subunit 12B
Gene Symbol
MVB12B
HGNC ID
HGNC:23368
ORF Size (aa)
666
ORF Size (bp)
666 bp
RefSeq ID
NM_033446
RefSeq Synonyms
NM_033446, NM_001011703, BC028675,
Species
human
UniGene ID
Hs.162659
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.