human DIO1 Adenovirus
This is an Adenovirus expressing Human LAMTOR4.
ADV-206994
Ad-h-DIO1
Ready-to-use Adenovirus expressing Human DIO1 (iodothyronine deiodinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
5DI; TXDI1
Description (Vector)
DIO1 is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.
Gene ID
1733
Gene Name (Vector)
iodothyronine deiodinase 1
Gene Symbol
DIO1
HGNC ID
HGNC:2883
ORF Size (aa)
486
RefSeq ID
NM_000792
RefSeq Synonyms
NM_213593, NM_001324316, NM_001039716, NM_001039715, NM_000792, BC107171, BC107170, BC017955,
Species
human
UniGene ID
Hs.251415
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.