human DDX20 Adenovirus
This is an Adenovirus expressing Human DDX20.
ADV-206738
Ad-h-DDX20
Ready-to-use Adenovirus expressing Human DDX20 (DEAD-box helicase 20). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
component of gems 3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD-box protein DP103; DP103; GEMIN3; gemin-3; probable ATP-dependent RNA helicase DDX20; SMN-interacting protein
Description (eCommerce)
DDX20 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. Some members of the DEAD box proteins also exhibit functions involved in transcriptional regulation. In addition to its role in snRNP assembly, DDX20 can function as a transcriptional repressor.
Description (Vector)
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.
Gene ID
11218
Gene Name (eCommerce)
DEAD-box helicase 20
Gene Name (Vector)
DEAD-box helicase 20
Gene Symbol
DDX20
HGNC ID
HGNC:2743
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2475
ORF Size (bp)
2475 bp
Protein Name (eCommerce)
Probable ATP-dependent RNA helicase DDX20
RefSeq ID
NM_007204
RefSeq Synonyms
NM_007204, BC034953, BC031062, BC011556,
Research Areas
Apoptosis,Cytoskeleton,Gene Expression,Helicase Activity,mRNA Processing,mRNA Splicing,RNA Processing,RNA Transport,Spliceosome,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
DDX20 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. Some members of the DEAD box proteins also exhibit functions involved in transcriptional regulation. In addition to its role in snRNP assembly, DDX20 can function as a transcriptional repressor.
UniGene ID
Hs.591405
UniProt ID (eCommerce)
Q9UHI6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.