human CASC5 Adenovirus

Name 
Ad-h-CASC5
Cat No 
ADV-204104
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human CASC5.

ADV-204104
Ad-h-CASC5

Ready-to-use Adenovirus expressing Human KNL1 (kinetochore scaffold 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AF15Q14; ALL1-fused gene from chromosome 15q14 protein; Blinkin; blinkin, bub-linking kinetochore protein; Bub-linking kinetochore protein; cancer susceptibility candidate 5; cancer susceptibility candidate gene 5 protein; cancer/testis antigen 29; CASC5; CT29; D40; hKNL-1; hSpc105; kinetochore null 1 homolog; kinetochore scaffold 1; kinetochore-null protein 1; MCPH4; microcephaly, primary autosomal recessive 4; PPP1R55; Protein CASC5; Protein D40/AF15q14; protein phosphatase 1, regulatory subunit 55; Spc7
Description (eCommerce)
Cancer susceptibility candidate gene 5 protein (CASC5) is predominantly expressed in testis and widely expressed in various human tumor cell lines and primary tumors from various tissues and organs. CASC5 is most frequently expressed in lung cancer and has been identified as a fusion-partner of the mixed lineage leukemia (MLL) gene, a gene often activated by chromosomal translocation in leukemias. CASC5 has also been identified as a component of the Mis12 kinetochore complex that is required for proper chromosome segregation.
Gene ID
57082
Gene Name (eCommerce)
kinetochore scaffold 1
Gene Name (Vector)
kinetochore scaffold 1
Gene Symbol
KNL1
HGNC ID
HGNC:24054
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7029
ORF Size (bp)
7029 bp
Protein Name (eCommerce)
Protein CASC5
RefSeq ID
NM_144508
RefSeq Synonyms
NM_170589, NM_144508, BC172422,
Research Areas
Cancer,Cell Biology,Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Phosphatase,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,neurobiology
Species
human
Target Sentence
Cancer susceptibility candidate gene 5 protein (CASC5) is predominantly expressed in testis and widely expressed in various human tumor cell lines and primary tumors from various tissues and organs. CASC5 is most frequently expressed in lung cancer and has been identified as a fusion-partner of the mixed lineage leukemia (MLL) gene, a gene often activated by chromosomal translocation in leukemias. CASC5 has also been identified as a component of the Mis12 kinetochore complex that is required for proper chromosome segregation.
UniGene ID
Hs.181855
UniProt ID (eCommerce)
Q8NG31

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.