human C8ORF4 Adenovirus
This is an Adenovirus expressing Human C8ORF4.
ADV-203725
Ad-h-C8ORF4
Ready-to-use Adenovirus expressing Human C8orf4 (chromosome 8 open reading frame 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TC-1; TC1
Description (Vector)
C8orf4 encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
Gene ID
56892
Gene Name (Vector)
chromosome 8 open reading frame 4
Gene Symbol
C8orf4
HGNC ID
HGNC:1357
ORF Size (aa)
321
ORF Size (bp)
321 bp
RefSeq ID
NM_020130
RefSeq Synonyms
NM_020130, BC021672, BC020623,
Species
human
UniGene ID
Hs.591849
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.