human BLOC1S3 Adenovirus

Name 
Ad-h-BLOC1S3
Cat No 
ADV-202170
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human APOBEC3C.

ADV-202170
Ad-h-BLOC1S3

Ready-to-use Adenovirus expressing Human BLOC1S3 (biogenesis of lysosomal organelles complex 1 subunit 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
biogenesis of lysosome-related organelles complex 1 subunit 3; biogenesis of lysosome-related organelles complex-1, subunit 3; BLOC-1 subunit 3; BLOS3; HPS8; reduced pigmentation, mouse, homolog of; RP
Description (eCommerce)
BLOC1S3 is a component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. It plays a role in intracellular vesicle trafficking [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6QNY0].
Description (Vector)
BLOC1S3 encodes a protein that is a component of the BLOC1 multi-subunit protein complex. This complex is necessary for the biogenesis of specialized organelles of the endosomal-lysosomal system, including platelet dense granules and melanosomes. Mutations in this gene cause Hermansky-Pudlak syndrome 8, a disease characterized by lysosomal storage defects, bleeding due to platelet storage pool deficiency, and oculocutaneous albinism.
Gene ID
388552
Gene Name (eCommerce)
biogenesis of lysosomal organelles complex 1 subunit 3
Gene Name (Vector)
biogenesis of lysosomal organelles complex 1 subunit 3
Gene Symbol
BLOC1S3
HGNC ID
HGNC:20914
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
609
ORF Size (bp)
609 bp
Protein Name (eCommerce)
Biogenesis of lysosome-related organelles complex 1 subunit 3
RefSeq ID
NM_212550
RefSeq Synonyms
NM_212550, BC151152, BC151151,
Research Areas
Golgi Apparatus,Immunology,Neurobiology,Neurodevelopment,Transport
Research Areas (Faceted)
cell_biology,immunology,neurobiology,developmental_biology
Species
human
Target Sentence
BLOC1S3 is a component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. It plays a role in intracellular vesicle trafficking [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6QNY0].
UniGene ID
Hs.719016
UniProt ID (eCommerce)
Q6QNY0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.