human ATRX Adenovirus

Name 
Ad-h-ATRX
Cat No 
ADV-201809
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ANKRD40.

ADV-201809
Ad-h-ATRX

Ready-to-use Adenovirus expressing Human ATRX (ATRX, chromatin remodeler). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); ATP-dependent helicase ATRX; JMS; MRX52; RAD54; RAD54L; transcriptional regulator ATRX; XH2; X-linked helicase II; X-linked nuclear protein; XNP; ZNF-HX
Description (eCommerce)
ATRX (alpha-thalassemia mental retardation X-linked) is a chromatin remodeling protein and transacting regulator of globin gene expression that has been linked to several X-linked mental retardation syndromes and hematologic diseases such as myelodysplasia. ATRX possesses an ATPase/helicase domain and is related to the SWI/SNF family of proteins. Mutations in ATRX have been demonstrated to cause changes in DNA methylation patterns and gene expression important to development.
Description (Vector)
ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene ID
546
Gene Name (eCommerce)
ATRX, chromatin remodeler
Gene Name (Vector)
ATRX, chromatin remodeler
Gene Symbol
ATRX
HGNC ID
HGNC:886
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6864
ORF Size (bp)
6864 bp
Protein Name (eCommerce)
Transcriptional regulator ATRX
RefSeq ID
NM_000489
RefSeq Synonyms
NM_138270, NM_000489, BC156296,
Research Areas
Brain Development,DNA Damage/Repair,Helicase Activity,Immunology,Neurobiology,Neurodevelopment,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
genetics,transcription_translation,cell_biology,immunology,neurobiology,developmental_biology
Species
human
Target Sentence
ATRX (alpha-thalassemia mental retardation X-linked) is a chromatin remodeling protein and transacting regulator of globin gene expression that has been linked to several X-linked mental retardation syndromes and hematologic diseases such as myelodysplasia. ATRX possesses an ATPase/helicase domain and is related to the SWI/SNF family of proteins. Mutations in ATRX have been demonstrated to cause changes in DNA methylation patterns and gene expression important to development.
UniGene ID
Hs.653797
UniProt ID (eCommerce)
P46100

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.