human ATF1 Adenovirus

Name 
Ad-h-ATF1
Cat No 
ADV-201613
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human AMTN.

ADV-201613
Ad-h-ATF1

Ready-to-use Adenovirus expressing Human ATF1 (activating transcription factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Activating transcription factor 1; cAMP-dependent transcription factor ATF-1; cyclic AMP-dependent transcription factor ATF-1; EWS-ATF1; FUS/ATF-1; Protein TREB36; TREB36
Description (eCommerce)
ATF1 (activating transcription factor 1) is a transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters.
Description (Vector)
ATF1 encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. ATF1 has a pseudogene on chromosome 6.
Gene ID
466
Gene Name (eCommerce)
activating transcription factor 1
Gene Name (Vector)
activating transcription factor 1
Gene Symbol
ATF1
HGNC ID
HGNC:783
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
816
ORF Size (bp)
816 bp
Protein Name (eCommerce)
Cyclic AMP-dependent transcription factor ATF-1
RefSeq ID
NM_005171
RefSeq Synonyms
NM_005171, BC029619,
Research Areas
Breast Cancer,Cancer,DNA Replication,EGFR Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,MAPK Signaling,Neurobiology,Neurodevelopment,NGF Signaling,Prostate Cancer,Signal Transduction,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
ATF1 (activating transcription factor 1) is a transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters.
UniGene ID
Hs.648565
UniProt ID (eCommerce)
P18846

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.