human APPL1 Adenovirus
This is an Adenovirus expressing Human APPL1.
ADV-201223
Ad-h-APPL1
Ready-to-use Adenovirus expressing Human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein containing pH domain, PTB domain and leucine zipper motif 1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; AKT2 interactor; APPL; DCC-interacting protein 13-alpha; DIP13alpha; dip13-alpha; MODY14; signaling adaptor protein DIP13alpha
Description (eCommerce)
APPL1 / DIP13alpha is required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. APPL1 / DIP13alpha links Rab5 to nuclear signal transduction [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UKG1].
Description (Vector)
APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
Gene ID
26060
Gene Name (eCommerce)
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Gene Name (Vector)
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Gene Symbol
APPL1
HGNC ID
HGNC:24035
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2130
ORF Size (bp)
2130 bp
Protein Name (eCommerce)
DCC-interacting protein 13-alpha
RefSeq ID
NM_012096
RefSeq Synonyms
NM_012096, BC028599,
Research Areas
Apoptosis,Cancer,Cell Cycle,Colorectal Cancer,EGFR Signaling,Insulin Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
APPL1 / DIP13alpha is required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. APPL1 / DIP13alpha links Rab5 to nuclear signal transduction [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UKG1].
UniGene ID
Hs.476415
UniProt ID (eCommerce)
Q9UKG1
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.