human APOC2 Adenovirus
This is an Adenovirus expressing Human APOC2.
ADV-201192
Ad-h-APOC2
Ready-to-use Adenovirus expressing Human APOC2 (apolipoprotein C-II). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
APO-CII; APOC-II; Apolipoprotein C2; apolipoprotein C-II
Description (eCommerce)
ApoCII contains 78 amino acid residues. The m.w. is 8.5 kDa (Jackson et al., 1977). The lipid-binding domain of Apo CII is localized to a region in the N-terminal with a strongly amphipathic nature (Macphee et al., 1999). Apo CII is also one of the key components of the metabolism of total triacylglycerol-rich lipoproteins by activating lipoprotein lipase that hydrolyzes fatty acids from triacylglycerols in chylomicrons. (Kei et al., 2012)
Description (Vector)
APOC2 encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. APOC2 is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene.
Gene ID
344
Gene Name (eCommerce)
apolipoprotein C2
Gene Name (Vector)
apolipoprotein C-II
Gene Symbol
APOC2
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
219
ORF Size (bp)
219 bp
Protein Name (eCommerce)
Apolipoprotein C-II
RefSeq ID
NM_000483
RefSeq Synonyms
NM_000483, BC065270, BC005348,
Research Areas
Cardiovascular
Research Areas (Faceted)
cardiovascular
Species
human
Target Sentence
ApoCII contains 78 amino acid residues. The m.w. is 8.5 kDa (Jackson et al., 1977). The lipid-binding domain of Apo CII is localized to a region in the N-terminal with a strongly amphipathic nature (Macphee et al., 1999). Apo CII is also one of the key components of the metabolism of total triacylglycerol-rich lipoproteins by activating lipoprotein lipase that hydrolyzes fatty acids from triacylglycerols in chylomicrons. (Kei et al., 2012)
UniGene ID
Hs.75615
UniProt ID (eCommerce)
P02655
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.