human ANK1 Adenovirus
This is an Adenovirus expressing Human ADNP.
ADV-200923
Ad-h-ANK1
Ready-to-use Adenovirus expressing Human ANK1 (ankyrin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ANK; ANK-1; ankyrin 1, erythrocytic; ankyrin-1; ankyrin-R; erythrocyte ankyrin; SPH1; SPH2
Description (eCommerce)
Ankyrin 1 is a member of the ankyrin family of proteins that function to link integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Ankyrin 1 was first discovered in erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis [taken from NCBI Entrez Gene (Gene ID: 286].
Description (Vector)
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
Gene ID
286
Gene Name (eCommerce)
ankyrin 1
Gene Name (Vector)
ankyrin 1
Gene Symbol
ANK1
HGNC ID
HGNC:492
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5643
ORF Size (bp)
5643 bp
Protein Name (eCommerce)
Ankyrin-1
RefSeq ID
NM_000037
RefSeq Synonyms
NM_020480, NM_020478, NM_020477, NM_020476, NM_020475, NM_001142446, NM_001142445, NM_000037, BC156401, BC030957, BC007930,
Research Areas
Axon Guidance,Cancer,Cytoskeleton,Golgi Apparatus,Neurobiology,Signal Transduction
Research Areas (Faceted)
cancer,signal_transduction,neurobiology,cell_biology
Species
human
Target Sentence
Ankyrin 1 is a member of the ankyrin family of proteins that function to link integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Ankyrin 1 was first discovered in erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis [taken from NCBI Entrez Gene (Gene ID: 286].
UniGene ID
Hs.708861
UniProt ID (eCommerce)
P16157
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.