human ADSL Adenovirus

Name 
Ad-h-ADSL
Cat No 
ADV-200514
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ACSS1.

ADV-200514
Ad-h-ADSL

Ready-to-use Adenovirus expressing Human ADSL (adenylosuccinate lyase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
adenylosuccinase; adenylosuccinate lyase; ADSL; AMPS; ASASE; ASL
Description (eCommerce)
Adenylosuccinate Lyase / ADSL is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and, in some cases, growth retardation associated with muscle wasting and epilepsy [taken from NCBI Entrez Gene (Gene ID: 158)].
Description (Vector)
Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
158
Gene Name (eCommerce)
adenylosuccinate lyase
Gene Name (Vector)
adenylosuccinate lyase
Gene Symbol
ADSL
HGNC ID
HGNC:291
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1455
ORF Size (bp)
1455 bp
Protein Name (eCommerce)
Adenylosuccinate lyase
RefSeq ID
NM_000026
RefSeq Synonyms
NM_001317923, NM_001123378, NM_000026, BC000253,
Research Areas
Epilepsy,Hypoxia,Metabolism/Metabolic Process,Mitochondrion,Neurobiology
Research Areas (Faceted)
neurobiology,cell_biology,metabolism
Species
human
Target Sentence
Adenylosuccinate Lyase / ADSL is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and, in some cases, growth retardation associated with muscle wasting and epilepsy [taken from NCBI Entrez Gene (Gene ID: 158)].
UniGene ID
Hs.75527
UniProt ID (eCommerce)
P30566

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.