human ACIN1 Adenovirus

Name 
Ad-h-ACIN1
Cat No 
ADV-200192
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ACIN1.

ADV-200192
Ad-h-ACIN1

Ready-to-use Adenovirus expressing Human ACIN1 (apoptotic chromatin condensation inducer 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ACINUS; ACN; apoptotic chromatin condensation inducer in the nucleus; fSAP152; functional spliceosome-associated protein 152
Description (eCommerce)
Acinus (Apoptotic Chromatin Condensation Inducer of the Nucleus) has been demonstrated to play a dual role in apoptosis and mRNA splicing. A proteolytic fragment of acinus generated by caspase cleavage appears to mediate chromatin condensation and DNA fragmentation. Acinus is also part of the ASAP (apoptosis and splicing-associated protein) complex that is deposited at exon-exon junctions during RNA splicing. In this complex acinus may be involved in pre-mRNA splicing.
Description (Vector)
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
22985
Gene Name (eCommerce)
apoptotic chromatin condensation inducer 1
Gene Name (Vector)
apoptotic chromatin condensation inducer 1
Gene Symbol
ACIN1
HGNC ID
HGNC:17066
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3987
ORF Size (bp)
3987 bp
Protein Name (eCommerce)
Apoptotic chromatin condensation inducer in the nucleus
RefSeq ID
NM_014977
RefSeq Synonyms
NM_014977, NM_001164817, NM_001164816, NM_001164815, NM_001164814, BC140805,
Research Areas
Apoptosis,Gene Expression,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,RNA Transport,Spliceosome
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Acinus (Apoptotic Chromatin Condensation Inducer of the Nucleus) has been demonstrated to play a dual role in apoptosis and mRNA splicing. A proteolytic fragment of acinus generated by caspase cleavage appears to mediate chromatin condensation and DNA fragmentation. Acinus is also part of the ASAP (apoptosis and splicing-associated protein) complex that is deposited at exon-exon junctions during RNA splicing. In this complex acinus may be involved in pre-mRNA splicing.
UniGene ID
Hs.124490
UniProt ID (eCommerce)
Q9UKV3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.