human ABCC8 Adenovirus
This is an Adenovirus expressing Human ABCC8.
ADV-200083
Ad-h-ABCC8
Ready-to-use Adenovirus expressing Human ABCC8 (ATP binding cassette subfamily C member 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ABC36; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; SUR1delta2; TNDM2
Description (Vector)
ABCC8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
Gene ID
6833
Gene Name (Vector)
ATP binding cassette subfamily C member 8
Gene Symbol
ABCC8
HGNC ID
HGNC:59
ORF Size (aa)
4746
ORF Size (bp)
4746 bp
RefSeq ID
NM_000352
RefSeq Synonyms
NM_001287174, NM_000352, BC167829,
Species
human
UniGene ID
Hs.54470
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.