rat RGD1308302 Over-expression AAV

Name 
AAV-r-RGD1308302
Cat No 
AAV-292140
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Rat Rrp8.

AAV-292140
AAV-r-RGD1308302

Ready-to-use AAV expressing Rat Rrp8 (ribosomal RNA processing 8, methyltransferase, homolog (yeast)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
RGD1308302
Description (Vector)
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Gene ID
308911
Gene Name (Vector)
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
Gene Symbol
Rrp8
ORF Size (aa)
1374
ORF Size (bp)
1374 bp
RefSeq ID
NM_001008346
RefSeq Synonyms
NM_001008346, BC085119,
Species
rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.