mouse PPP4R2 Over-expression AAV

Name 
AAV-m-PPP4R2
Cat No 
AAV-280997
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Ppp4r2.

AAV-280997
AAV-m-PPP4R2

Ready-to-use AAV expressing Mouse Ppp4r2 (protein phosphatase 4, regulatory subunit 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BE691708; C230060M08Rik
Description (Vector)
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Gene ID
232314
Gene Name (Vector)
protein phosphatase 4, regulatory subunit 2
Gene Symbol
Ppp4r2
ORF Size (aa)
1251
ORF Size (bp)
1251 bp
RefSeq ID
NM_182939
RefSeq Synonyms
NM_182939, BC110429, BC098464, BC056340,
Species
mouse
UniGene ID
Mm.399622

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.