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mouse VRK2 Over-expression AAV

Name 
AAV-m-VRK2
Cat No 
AAV-276082
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Vrk2.

AAV-276082
AAV-m-VRK2

Ready-to-use AAV expressing Mouse Vrk2 (vaccinia related kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
2810003O05Rik; AI447698
Description (Vector)
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes, reduces JNK phosphorylation and AP1-dependent transcription. Phosphorylates: 'Thr-18' of p53/TP53, casein, MBP, histone H2B, histone H3 and MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS|Function: Isoform 2 phosphorylates: 'Thr-18' of p53/TP53, casein, MBP, histone H2B, histone H3 and MAPK8IP1. Stabilizes p53/TP53 and activates its transcriptional activity. Reduces p53/TP53 ubiquitination by MDM2 and promotes its acetylation by EP300.
Gene ID
69922
Gene Name (Vector)
vaccinia related kinase 2
Gene Symbol
Vrk2
ORF Size (aa)
1365
ORF Size (bp)
1365 bp
RefSeq ID
NM_027260
RefSeq Synonyms
NM_027260, NM_001252447, BC013520,
Species
mouse
UniGene ID
Mm.285351

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.