mouse UIMC1 Over-expression AAV
This is an AAV expressing Mouse Uimc1.
AAV-275614
AAV-m-UIMC1
Ready-to-use AAV expressing Mouse Uimc1 (ubiquitin interaction motif containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9430016E08Rik; D330018D10Rik; D630032M02Rik; RIP110; Rxrip110
Description (Vector)
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly Act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Gene ID
20184
Gene Name (Vector)
ubiquitin interaction motif containing 1
Gene Symbol
Uimc1
ORF Size (aa)
2184
ORF Size (bp)
2184 bp
RefSeq ID
NM_011307
RefSeq Synonyms
NM_011307, NM_001293660, BC040808,
Species
mouse
UniGene ID
Mm.259301
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.