mouse TRAF3 Over-expression AAV

Name 
AAV-m-TRAF3
Cat No 
AAV-274889
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse TRAF3.

AAV-274889
AAV-m-TRAF3

Ready-to-use AAV expressing Mouse TRAF3 (TNF receptor-associated factor 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AI528849; amn; CAP-1; CD40bp; CRAF1; LAP1; T-BAM
Description (Vector)
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Gene ID
22031
Gene Name (Vector)
TNF receptor-associated factor 3
Gene Symbol
TRAF3
ORF Size (aa)
1704
ORF Size (bp)
1704 bp
RefSeq ID
NM_011632
RefSeq Synonyms
NM_011632, NM_001286122, NM_001048206, BC137635, BC137634,
Species
mouse
UniGene ID
Mm.27431

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.