mouse TRAF3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse TRAF3.
shAAV-274889
AAV-m-TRAF3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse TRAF3 (TNF receptor-associated factor 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI528849; amn; CAP-1; CD40bp; CRAF1; LAP1; T-BAM
Description (Vector)
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Gene ID
22031
Gene Name (Vector)
TNF receptor-associated factor 3
Gene Symbol
TRAF3
ORF Size (aa)
1704
ORF Size (bp)
1704 bp
RefSeq ID
NM_011632
RefSeq Synonyms
NM_011632, NM_001286122, NM_001048206, BC137635, BC137634,
Species
mouse
UniGene ID
Mm.27431
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.