mouse TNFRSF4 Over-expression AAV

Name 
AAV-m-TNFRSF4
Cat No 
AAV-274716
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Tnfrsf4.

AAV-274716
AAV-m-TNFRSF4

Ready-to-use AAV expressing Mouse Tnfrsf4 (tumor necrosis factor receptor superfamily, member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ACT35;CD antigen CD134;CD134;Ly-70;Ox40;OX40 antigen;OX40L receptor;tax-transcriptionally activated glycoprotein 1;tumor necrosis factor receptor superfamily member 4;Txgp1;TXGP1L
Description (eCommerce)
OX40/CD134 is a member of the TNF-receptor superfamily that has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested OX40/CD134 plays a role in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [taken from NCBI Entrez Gene (Gene ID: 3659)].
Description (Vector)
Receptor for TNFSF4/OX40L/GP34.
Gene ID
22163
Gene Name (eCommerce)
tumor necrosis factor receptor superfamily, member 4
Gene Name (Vector)
tumor necrosis factor receptor superfamily, member 4
Gene Symbol
Tnfrsf4
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
819
Protein Name (eCommerce)
Tumor necrosis factor receptor superfamily member 4
RefSeq ID
NM_011659
RefSeq Synonyms
NM_011659, BC139266, BC139239,
Research Areas
Apoptosis,Cancer,Immune cells & tumor markers,Immune-checkpoints,Immunology,Immuno-Oncology,Signal Transduction,T cell markers,T Cell Receptor Signaling
Research Areas (Faceted)
cancer,cell_biology,immunology,immuno_oncology,signal_transduction
Species
mouse
Target Sentence
OX40/CD134 is a member of the TNF-receptor superfamily that has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested OX40/CD134 plays a role in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [taken from NCBI Entrez Gene (Gene ID: 3659)].
UniGene ID
Mm.13885
UniProt ID (eCommerce)
P47741

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.