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human TNFRSF4 shRNA silencing Adenovirus

Name 
Ad-h-TNFRSF4-shRNA
Cat No 
shADV-226092
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TNFRSF4.

shADV-226092
Ad-h-TNFRSF4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TNFRSF4 (TNF receptor superfamily member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ACT35; ACT35 antigen; ATC35 antigen; CD antigen CD134; CD134; CD134 antigen; IMD16; lymphoid activation antigene ACT35; OX40; OX40 antigen; OX40 cell surface antigen; OX40 homologue; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor; tumor necrosis factor receptor superfamily member 4; TXGP1L
Description (eCommerce)
OX40/CD134 is a member of the TNF-receptor superfamily that has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested OX40/CD134 plays a role in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [taken from NCBI Entrez Gene (Gene ID: 3659)].
Description (Vector)
TNFRSF4 is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
Gene ID
7293
Gene Name (eCommerce)
TNF receptor superfamily member 4
Gene Name (Vector)
TNF receptor superfamily member 4
Gene Symbol
TNFRSF4
HGNC ID
HGNC:11918
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
834
Protein Name (eCommerce)
Tumor necrosis factor receptor superfamily member 4
RefSeq ID
NM_003327
RefSeq Synonyms
NM_003327, BC105072, BC105070,
Research Areas
Apoptosis,Cancer,Immunology,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
OX40/CD134 is a member of the TNF-receptor superfamily that has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested OX40/CD134 plays a role in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [taken from NCBI Entrez Gene (Gene ID: 3659)].
UniGene ID
Hs.129780
UniProt ID (eCommerce)
P43489

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.