mouse TMEM66 Over-expression AAV

Name 
AAV-m-TMEM66
Cat No 
AAV-274589
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Saraf.

AAV-274589
AAV-m-TMEM66

Ready-to-use AAV expressing Mouse Saraf (store-operated calcium entry-associated regulatory factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
1810045K07Rik; Tmem66
Description (Vector)
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
Gene ID
67887
Gene Name (Vector)
store-operated calcium entry-associated regulatory factor
Gene Symbol
Saraf
ORF Size (aa)
1092
ORF Size (bp)
1092 bp
RefSeq ID
NM_026432
RefSeq Synonyms
NM_026432, BC024888, BC022616, BC013497,
Species
mouse
UniGene ID
Mm.290353

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.