mouse THAP1 Over-expression AAV

Name
AAV-m-THAP1

Cat No
AAV-274138

Availability
4-5 weeks

This is an AAV expressing Mouse Thap1.

AAV-274138

AAV-m-THAP1

Ready-to-use AAV expressing Mouse Thap1 (THAP domain containing, apoptosis associated protein 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

4833431A01Rik; AW490810

Description (Vector)

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.

Gene ID

73754

Gene Name (Vector)

THAP domain containing, apoptosis associated protein 1

Gene Symbol

Thap1

ORF Size (aa)

633

ORF Size (bp)

633 bp

RefSeq ID

NM_199042

RefSeq Synonyms

NM_199042, BC038639,

Species

mouse

UniGene ID

Mm.383241

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.