mouse SAV1 Over-expression AAV
This is an AAV expressing Mouse Sav1.
AAV-271381
AAV-m-SAV1
Ready-to-use AAV expressing Mouse Sav1 (salvador family WW domain containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4
Description (Vector)
Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Gene ID
64010
Gene Name (Vector)
salvador family WW domain containing 1
Gene Symbol
Sav1
ORF Size (aa)
1161
ORF Size (bp)
1161 bp
RefSeq ID
NM_022028
RefSeq Synonyms
NM_022028, BC019377,
Species
mouse
UniGene ID
Mm.390480
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.