mouse REST Over-expression AAV

Name 
AAV-m-REST
Cat No 
AAV-270409
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Rest.

AAV-270409
AAV-m-REST

Ready-to-use AAV expressing Mouse Rest (RE1-silencing transcription factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
2610008J04Rik; AA407358; NRSF; REST4
Description (Vector)
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Gene ID
19712
Gene Name (Vector)
RE1-silencing transcription factor
Gene Symbol
Rest
ORF Size (aa)
3249
ORF Size (bp)
3249 bp
RefSeq ID
NM_011263
RefSeq Synonyms
NM_011263, BC127065,
Species
mouse
UniGene ID
Mm.392264

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.