mouse NEK2 Over-expression AAV
This is an AAV expressing Mouse Nek2.
AAV-265648
AAV-m-NEK2
Ready-to-use AAV expressing Mouse Nek2 (NIMA (never in mitosis gene a)-related expressed kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AA617254; C77054
Description (Vector)
Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
Gene ID
18005
Gene Name (Vector)
NIMA (never in mitosis gene a)-related expressed kinase 2
Gene Symbol
Nek2
ORF Size (aa)
1332
ORF Size (bp)
1332 bp
RefSeq ID
NM_010892
RefSeq Synonyms
NM_010892, BC057576, BC011316, BC010302,
Species
mouse
UniGene ID
Mm.403999
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.