mouse MAML1 Over-expression AAV

Name 
AAV-m-MAML1
Cat No 
AAV-264140
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Maml1.

AAV-264140
AAV-m-MAML1

Ready-to-use AAV expressing Mouse Maml1 (mastermind like 1 (Drosophila)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AI644666; AW743257; D930008C07Rik; Mam-1; Mam1; mKIAA0200
Description (Vector)
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Gene ID
103806
Gene Name (Vector)
mastermind like 1 (Drosophila)
Gene Symbol
Maml1
ORF Size (aa)
2364
ORF Size (bp)
2364 bp
RefSeq ID
NM_175334
RefSeq Synonyms
NM_175334, BC094599,
Species
mouse
UniGene ID
Mm.51116

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.