mouse MAFA Over-expression AAV

Name 
AAV-m-MAFA
Cat No 
AAV-264082
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Mafa.

AAV-264082
AAV-m-MAFA

Ready-to-use AAV expressing Mouse Mafa (v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Mafa homolog; pancreatic beta-cell-specific transcriptional activator; RIPE3b1; transcription factor MafA; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
Description (eCommerce)
MafA is a member of the Maf basic leucine-zipper containing transcription factor family. MafA is an islet-enriched protein that plays a role in beta cell-specific and glucose-responsive insulin gene transcription. MafA is expressed exclusively in cell populations that will become islet beta cells.
Description (Vector)
Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Gene ID
378435
Gene Name (eCommerce)
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
Gene Name (Vector)
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
Gene Symbol
Mafa
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
1077
ORF Size (bp)
1077 bp
Protein Name (eCommerce)
Transcription factor MafA
RefSeq ID
NM_194350
RefSeq Synonyms
NM_194350, BC156190,
Research Areas
Cancer,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,transcription_translation
Species
mouse
Target Sentence
MafA is a member of the Maf basic leucine-zipper containing transcription factor family. MafA is an islet-enriched protein that plays a role in beta cell-specific and glucose-responsive insulin gene transcription. MafA is expressed exclusively in cell populations that will become islet beta cells.
UniGene ID
Mm.309589
UniProt ID (eCommerce)
Q8CF90

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.