mouse LAIR1 Over-expression AAV

Name 
AAV-m-LAIR1
Cat No 
AAV-263226
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Lair1.

AAV-263226
AAV-m-LAIR1

Ready-to-use AAV expressing Mouse Lair1 (leukocyte-associated Ig-like receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
5133400O11Rik; BB115266; D7Bwg0421e; Lair-1
Description (Vector)
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Gene ID
52855
Gene Name (Vector)
leukocyte-associated Ig-like receptor 1
Gene Symbol
Lair1
ORF Size (aa)
792
ORF Size (bp)
792 bp
RefSeq ID
NM_178611
RefSeq Synonyms
NM_178611, NM_001302683, NM_001302682, NM_001302681, NM_001302677, NM_001302676, NM_001302675, NM_001113474, BC025901,
Species
mouse
UniGene ID
Mm.290880

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.