mouse LAIR1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Lair1.
shAAV-263226
AAV-m-LAIR1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Lair1 (leukocyte-associated Ig-like receptor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
5133400O11Rik; BB115266; D7Bwg0421e; Lair-1
Description (Vector)
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Gene ID
52855
Gene Name (Vector)
leukocyte-associated Ig-like receptor 1
Gene Symbol
Lair1
ORF Size (aa)
792
ORF Size (bp)
792 bp
RefSeq ID
NM_178611
RefSeq Synonyms
NM_178611, NM_001302683, NM_001302682, NM_001302681, NM_001302677, NM_001302676, NM_001302675, NM_001113474, BC025901,
Species
mouse
UniGene ID
Mm.290880
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.