mouse GRK6 Over-expression AAV

Name 
AAV-m-GRK6
Cat No 
AAV-260783
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Grk6.

AAV-260783
AAV-m-GRK6

Ready-to-use AAV expressing Mouse Grk6 (G protein-coupled receptor kinase 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Gprk6
Description (Vector)
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Gene ID
26385
Gene Name (Vector)
G protein-coupled receptor kinase 6
Gene Symbol
Grk6
ORF Size (aa)
1770
ORF Size (bp)
1770 bp
RefSeq ID
NM_011938
RefSeq Synonyms
NM_011938, NM_001286066, NM_001286065, NM_001286064, NM_001286063, NM_001112711, NM_001038018, BC075719,
Species
mouse
UniGene ID
Mm.10193

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.