mouse FZR1 Over-expression AAV

Name 
AAV-m-FZR1
Cat No 
AAV-259755
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Fzr1.

AAV-259755
AAV-m-FZR1

Ready-to-use AAV expressing Mouse Fzr1 (fizzy/cell division cycle 20 related 1 (Drosophila)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AW108046; Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1
Description (Vector)
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Gene ID
56371
Gene Name (Vector)
fizzy/cell division cycle 20 related 1 (Drosophila)
Gene Symbol
Fzr1
ORF Size (aa)
1482
ORF Size (bp)
1482 bp
RefSeq ID
NM_019757
RefSeq Synonyms
NM_019757, BC006616,
Species
mouse
UniGene ID
Mm.24202

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.