mouse FZR1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Fzr1.
shAAV-259755
AAV-m-FZR1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Fzr1 (fizzy/cell division cycle 20 related 1 (Drosophila)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW108046; Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1
Description (Vector)
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Gene ID
56371
Gene Name (Vector)
fizzy/cell division cycle 20 related 1 (Drosophila)
Gene Symbol
Fzr1
ORF Size (aa)
1482
ORF Size (bp)
1482 bp
RefSeq ID
NM_019757
RefSeq Synonyms
NM_019757, BC006616,
Species
mouse
UniGene ID
Mm.24202
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.