mouse FBXW5 Over-expression AAV

Name 
AAV-m-FBXW5
Cat No 
AAV-259272
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Fbxw5.

AAV-259272
AAV-m-FBXW5

Ready-to-use AAV expressing Mouse Fbxw5 (F-box and WD-40 domain protein 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AI159739; Fbw5
Description (Vector)
Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
Gene ID
30839
Gene Name (Vector)
F-box and WD-40 domain protein 5
Gene Symbol
Fbxw5
ORF Size (aa)
1722
ORF Size (bp)
1722 bp
RefSeq ID
NM_013908
RefSeq Synonyms
NM_013908, BC010776,
Species
mouse
UniGene ID
Mm.29170

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.