mouse DISC1 Over-expression AAV
This is an AAV expressing Mouse Disc1.
AAV-257199
AAV-m-DISC1
Ready-to-use AAV expressing Mouse Disc1 (disrupted in schizophrenia 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
Gene ID
244667
Gene Name (Vector)
disrupted in schizophrenia 1
Gene Symbol
Disc1
ORF Size (aa)
2556
ORF Size (bp)
2556 bp
RefSeq ID
NM_174854
RefSeq Synonyms
NM_174854, NM_174853, BC148606,
Species
mouse
UniGene ID
Mm.233504
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.