mouse CIB1 Over-expression AAV

Name 
AAV-m-CIB1
Cat No 
AAV-255495
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Cib1.

AAV-255495
AAV-m-CIB1

Ready-to-use AAV expressing Mouse Cib1 (calcium and integrin binding 1 (calmyrin)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Cibkip; Kip; Prkdcip
Description (Vector)
CIB1 may convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.
Gene ID
23991
Gene Name (Vector)
calcium and integrin binding 1 (calmyrin)
Gene Symbol
Cib1
ORF Size (aa)
576
ORF Size (bp)
576 bp
RefSeq ID
NM_011870
RefSeq Synonyms
NM_011870, NM_001291276, NM_001291275, BC054385, BC003714,
Species
mouse
UniGene ID
Mm.30217

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.