mouse BNIP3 Over-expression AAV

Name 
AAV-m-BNIP3
Cat No 
AAV-254045
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Bnip3.

AAV-254045
AAV-m-BNIP3

Ready-to-use AAV expressing Mouse Bnip3 (BCL2/adenovirus E1B interacting protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Nip3
Description (Vector)
Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
Gene ID
12176
Gene Name (Vector)
BCL2/adenovirus E1B interacting protein 3
Gene Symbol
Bnip3
ORF Size (aa)
564
ORF Size (bp)
564 bp
RefSeq ID
NM_009760
RefSeq Synonyms
NM_009760, BC046603,
Species
mouse
UniGene ID
Mm.378890

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.