mouse ARHGEF18 Over-expression AAV

Name 
AAV-m-ARHGEF18
Cat No 
AAV-252973
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Arhgef18.

AAV-252973
AAV-m-ARHGEF18

Ready-to-use AAV expressing Mouse Arhgef18 (rho/rac guanine nucleotide exchange factor (GEF) 18). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AI467246; D030053O22Rik
Description (Vector)
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.
Gene ID
102098
Gene Name (Vector)
rho/rac guanine nucleotide exchange factor (GEF) 18
Gene Symbol
Arhgef18
ORF Size (aa)
3066
ORF Size (bp)
3066 bp
RefSeq ID
NM_133962
RefSeq Synonyms
NM_133962, BC060639,
Species
mouse
UniGene ID
Mm.170461

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.