mouse ACCN2 Over-expression AAV
This is an AAV expressing Mouse Asic1.
AAV-251897
AAV-m-ACCN2
Ready-to-use AAV expressing Mouse Asic1 (acid-sensing (proton-gated) ion channel 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Accn2; AI843610; ASIC; ASIC1a; B530003N02Rik; BNaC2
Description (Vector)
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear (By similarity).
Gene ID
11419
Gene Name (Vector)
acid-sensing (proton-gated) ion channel 1
Gene Symbol
Asic1
ORF Size (aa)
1581
ORF Size (bp)
1581 bp
RefSeq ID
NM_009597
RefSeq Synonyms
NM_009597, NM_001289791, BC067025,
Species
mouse
UniGene ID
Mm.440107
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.