human MAPT Over-expression AAV
This is an AAV expressing Human MAPT.
AAV-233559
AAV-h-MAPT
Ready-to-use AAV expressing Human MAPT (microtubule associated protein tau). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU
Description (Vector)
MAPT encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Gene ID
4137
Gene Name (Vector)
microtubule associated protein tau
Gene Symbol
MAPT
HGNC ID
HGNC:6893
ORF Size (aa)
1152
ORF Size (bp)
1152 bp
RefSeq ID
NM_005910
RefSeq Synonyms
NM_016841, NM_016835, NM_016834, NM_005910, NM_001203252, NM_001203251, NM_001123067, NM_001123066, BC114948,
Species
human
Related Citations
- Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein. AJ Moszczynski, etc, (2019), Acta Neuropathologica Communications
- Somatic Gene Transfer Using a Recombinant Adenoviral Vector (rAAV9) Encoding Pseudophosphorylated Human Thr175 Tau in Adult Rat Hippocampus Induces Tau Pathology.. AJ Moszczynski, etc, (2018), J Neuropathol Exp Neurol.
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.