human EVI5 Over-expression AAV

Name 
AAV-h-EVI5
Cat No 
AAV-231549
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human EVI5.

AAV-231549
AAV-h-EVI5

Ready-to-use AAV expressing Human EVI5 (ecotropic viral integration site 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
dJ846D11.1 (ecotropic viral integration site 5); ecotropic viral integration site 5 protein homolog; EVI-5; NB4S; neuroblastoma stage 4S gene protein
Description (eCommerce)
The EVI5 oncogene has been identified as a protein that is localized to the centrosome and mitotic spindle, and in association with the aurora B complex, facilitates cytokinesis. EVI5 also appears to prevent premature APC/C activation and mitotic progression by stabilizing the anaphase-promoting complex/cyclosome (APC/C) inhibitor, Emi1, as well as cyclin A. EVI5 has also been demonstrated to be a binding partner of the Rab11 GTPase that regulates intracellular transport and cytokinesis.
Gene ID
7813
Gene Name (eCommerce)
ecotropic viral integration site 5
Gene Name (Vector)
ecotropic viral integration site 5
Gene Symbol
EVI5
HGNC ID
HGNC:3501
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2430
ORF Size (bp)
2430 bp
Protein Name (eCommerce)
Ecotropic viral integration site 5 protein homolog
RefSeq ID
NM_005665
RefSeq Synonyms
NM_005665, NM_001308248, BC156793, BC141544,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
The EVI5 oncogene has been identified as a protein that is localized to the centrosome and mitotic spindle, and in association with the aurora B complex, facilitates cytokinesis. EVI5 also appears to prevent premature APC/C activation and mitotic progression by stabilizing the anaphase-promoting complex/cyclosome (APC/C) inhibitor, Emi1, as well as cyclin A. EVI5 has also been demonstrated to be a binding partner of the Rab11 GTPase that regulates intracellular transport and cytokinesis.
UniGene ID
Hs.594434
UniProt ID (eCommerce)
O60447

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.