human CFL1 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-230115
Availability:
Immediate
Name:
AAV-h-CFL1
This is an AAV expressing Human CFL1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- CFL1
- Gene Name
- cofilin 1
- Gene ID
- 1072
- Gene Synonyms
- CFL; cofilin; HEL-S-15
- ORF Size
- 501 bp
- RefSeq#
- BC018256
- Gene Description
- CFL1 can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.(supplied by OMIM, Apr 2004)
- UniGene ID
- Hs.
- HGNC ID
- HGNC:1874
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