human RNF31 Over-expression AAV

Name 
AAV-h-RNF31
Cat No 
AAV-230057
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RNF31.

AAV-230057
AAV-h-RNF31

Ready-to-use AAV expressing Human RNF31 (ring finger protein 31). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
E3 ubiquitin-protein ligase RNF31; HOIL-1-interacting protein; HOIP; Paul; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31; ZIBRA; zinc in-between-RING-finger ubiquitin-associated domain protein
Description (eCommerce)
RING finger protein 31 is an E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96EP0].
Description (Vector)
RNF31 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.
Gene ID
55072
Gene Name (eCommerce)
ring finger protein 31
Gene Name (Vector)
ring finger protein 31
Gene Symbol
RNF31
HGNC ID
HGNC:16031
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3219
ORF Size (bp)
3219 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase RNF31
RefSeq ID
NM_017999
RefSeq Synonyms
NM_017999, NM_001310332, BC017376, BC012077,
Research Areas
CD40 Signaling,Immunology,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
RING finger protein 31 is an E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96EP0].
UniGene ID
Hs.375217
UniProt ID (eCommerce)
Q96EP0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.