human MYC Over-expression AAV

avian myelocytomatosis viral oncogene homolog; bHLHe39; class E basic helix-loop-helix protein 39; c-Myc; MRTL; myc proto-oncogene protein; MYCC; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog

The Myc epitope tag is a commonly used epitope tag engineered onto the N- or C- terminus of a protein of interest so that the tagged protein can be analyzed and visualized using immunochemical methods. The recognized c-myc epitope represents amino acid residues 410-419, EQKLISEEDL, of human c-myc.

MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

4609

MYC proto-oncogene, bHLH transcription factor

v-myc avian myelocytomatosis viral oncogene homolog

MYC

HGNC:7553

9606.0

1365

1365 bp

Myc proto-oncogene protein

NM_002467

NM_002467, BC058901, BC000917, BC000141,

Apoptosis,B-cell Receptor Signaling,Bladder Cancer,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,Cell Cycle,Chromatin Remodeling,Colorectal Cancer,DNA Damage/Repair,EGFR Signaling,Gene Expression,Hippo Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Leukemia,LKB1 Signaling,Lung Cancer,MAPK Signaling,Metabolism/Metabolic Process,MicroRNAs in Cancer,Neurobiology,Neurodevelopment,Notch Signaling,PDGF Signaling,PI3K/Akt Signaling,Prolactin Signaling,Prostate Cancer,Signal Transduction,Telomeric Maintenance,TGF-beta Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,TSH Signaling,TSLP Signaling,Wnt Signaling

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,transcription_translation

human

The Myc epitope tag is a commonly used epitope tag engineered onto the N- or C- terminus of a protein of interest so that the tagged protein can be analyzed and visualized using immunochemical methods. The recognized c-myc epitope represents amino acid residues 410-419, EQKLISEEDL, of human c-myc.

Hs.

P01106