human YARS Over-expression AAV

Name 
AAV-h-YARS
Cat No 
AAV-227946
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human YARS.

AAV-227946
AAV-h-YARS

Ready-to-use AAV expressing Human YARS (tyrosyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CMTDIC; tyrosine tRNA ligase 1, cytoplasmic; tyrosine--tRNA ligase, cytoplasmic; tyrosyl--tRNA ligase; Tyrosyl-tRNA synthetase; tyrosyl-tRNA synthetase, cytoplasmic; TYRRS; YRS; YTS
Description (eCommerce)
The YARS gene encodes the protein Tyrosine--tRNA ligase, cytoplasmic, also known as Tyrosyl-tRNA synthetase. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution [taken from NCBI Entrez Gene (Gene ID: 8565)].
Description (Vector)
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.
Gene ID
8565
Gene Name (eCommerce)
tyrosyl-tRNA synthetase
Gene Name (Vector)
tyrosyl-tRNA synthetase
Gene Symbol
YARS
HGNC ID
HGNC:12840
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1587
ORF Size (bp)
1587 bp
Protein Name (eCommerce)
Tyrosine--tRNA ligase, cytoplasmic
RefSeq ID
NM_003680
RefSeq Synonyms
NM_003680, BC016689, BC004151, BC001933,
Research Areas
Apoptosis,Gene Expression,Interleukin Signaling,Neurobiology,Neurodegeneration,Neurodevelopment,RNA Binding,Signal Transduction,Translational Control,tRNA Binding
Research Areas (Faceted)
signal_transduction,cell_biology,genetics,transcription_translation,signal_transduction,immunology,neurobiology,developmental_biology,genetics,transcription_translation
Species
human
Target Sentence
The YARS gene encodes the protein Tyrosine--tRNA ligase, cytoplasmic, also known as Tyrosyl-tRNA synthetase. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution [taken from NCBI Entrez Gene (Gene ID: 8565)].
UniGene ID
Hs.706890
UniProt ID (eCommerce)
P54577

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.