human XRN2 Over-expression AAV

Name 
AAV-h-XRN2
Cat No 
AAV-227938
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human XRN2.

AAV-227938
AAV-h-XRN2

Ready-to-use AAV expressing Human XRN2 (5′-3′ exoribonuclease 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
5'-3' exoribonuclease 2; Dhm1-like protein; DHP protein
Description (eCommerce)
XRN2 is a 5’-to-3’ exoribonuclease involved in 3’-end mRNA processing. XRN2 is important for transcription termination and is responsible for degrading the downstream 3’-end-cleaved RNA. Recent studies show that XRN2 is recruited to 3’-end processing machinery by p54nrb/PSF.
Description (Vector)
XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known.
Gene ID
22803
Gene Name (eCommerce)
5'-3' exoribonuclease 2
Gene Name (Vector)
5'-3' exoribonuclease 2
Gene Symbol
XRN2
HGNC ID
HGNC:12836
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2853
ORF Size (bp)
2853 bp
Protein Name (eCommerce)
5'-3' exoribonuclease 2
RefSeq ID
NM_012255
RefSeq Synonyms
NM_012255, NM_001317960, BC160100, BC006417,
Research Areas
mRNA Processing,Protein Folding,RNA Processing,Spermatogenesis,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,transcription_translation
Species
human
Target Sentence
XRN2 is a 5’-to-3’ exoribonuclease involved in 3’-end mRNA processing. XRN2 is important for transcription termination and is responsible for degrading the downstream 3’-end-cleaved RNA. Recent studies show that XRN2 is recruited to 3’-end processing machinery by p54nrb/PSF.
UniGene ID
Hs.255932
UniProt ID (eCommerce)
Q9H0D6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.