human XRCC1 Over-expression AAV

Name
AAV-h-XRCC1

Cat No
AAV-227923

Availability
4-5 weeks

This is an AAV expressing Human XRCC1.

AAV-227923

AAV-h-XRCC1

Ready-to-use AAV expressing Human XRCC1 (X-ray repair cross complementing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DNA repair protein XRCC1; RCC; SCAR26; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1

Description (eCommerce)

X-ray repair cross-complementing protein 1 (XRCC1) has been identified as a gene that partially rescues a DNA repair defect and therefore plays a role in efficient repair of single-stranded breaks in DNA damage caused by ionizing radiation. XRCC1 interacts with human polynucleotide kinase, DNA polymerase-beta, and DNA ligase III in a multiprotein complex to execute the function of DNA repair.

Description (Vector)

XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Gene ID

7515

Gene Name (eCommerce)

X-ray repair cross complementing 1

Gene Name (Vector)

X-ray repair cross complementing 1

Gene Symbol

XRCC1

HGNC ID

HGNC:12828

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1902

ORF Size (bp)

1902 bp

Protein Name (eCommerce)

DNA repair protein XRCC1

RefSeq ID

NM_006297

RefSeq Synonyms

NM_006297, BC023593,

Research Areas

DNA Damage/Repair,Hypoxia,Phospho-specific

Research Areas (Faceted)

cell_biology,genetics,transcription_translation

Species

human

Target Sentence

X-ray repair cross-complementing protein 1 (XRCC1) has been identified as a gene that partially rescues a DNA repair defect and therefore plays a role in efficient repair of single-stranded breaks in DNA damage caused by ionizing radiation. XRCC1 interacts with human polynucleotide kinase, DNA polymerase-beta, and DNA ligase III in a multiprotein complex to execute the function of DNA repair.

UniGene ID

Hs.98493

UniProt ID (eCommerce)

P18887

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.